Associate Director, Translational Medicine Lead

Role Overview

• Own and execute end-to-end translational strategies for assigned B-cell malignancy programs from preclinical through Phase 1/2 and, as needed, Phase 3, with clear decision points tied to dose, schedule and patient selection.
• Integrate human genetics, expression and clinical data to define indications, stratify patients and refine target populations across monotherapy and rational combinations.
• Design and interpret target engagement and pharmacodynamic biomarker readouts to enable data-driven dose selection and early proof of mechanism across multiple concurrent studies.
• Define and investigate mechanisms of resistance using longitudinal and relapse samples to inform next-line strategies and combination hypotheses.
• Analyze B-cell tumor biology, pathway interactions and microenvironment features in patient samples to guide combination design and strengthen translational rationale.
• Lead development, validation and deployment of fit-for-purpose assays (e.g., flow cytometry, IHC/IF, molecular, MRD-adjacent panels) internally and with external labs/CROs, aligned to clinical endpoints and timelines.
• Embed biomarker strategies and endpoints into protocols, sample manuals and statistical plans; partner with biosamples and precision diagnostics to ensure collection, traceability and, where relevant, CDx path alignment.
• Represent Translational Medicine on cross-functional teams, connect insights across the B-cell portfolio to inform indication expansion and combinations, and contribute to governance materials, study reports and Go/No-Go recommendations.
• Contribute translational and biomarker content for health authority interactions and filings; build coherent scientific narratives; present internally and in external forums to shape the field in B-cell translational research.

Requirements

• PhD in a relevant biological science (hematology-oncology, immunology, oncology, molecular biology, or related field); postdoctoral and/or industry experience required.
• Demonstrated experience with T-cell engaging bispecifics (e.g., CD3-targeting bispecifics, BiTEs) in an oncology/hematology development context.
• Demonstrated experience with antibody-drug conjugates (ADCs) in a hematology or oncology development context.
• Experience contributing to early phase oncology clinical trials, including biomarker plan development, protocol input, and sample analysis; exposure to Phase 3 trial biomarker strategies a plus.
• Demonstrated expertise in biomarker technologies such as flow cytometry, immunohistochemistry, molecular profiling, NGS, ctDNA, MRD assessment, cytokine/immune profiling, and other omics-based approaches as relevant to hematologic cancers.
• Established knowledge of B-cell malignancy biology spanning leukemia (B-ALL, B-CLL) and lymphoma (NHL), including disease pathogenesis, standard-of-care landscape, and mechanisms of therapeutic resistance.
• In-depth understanding of immunology and the tumor microenvironment in B-cell cancers, with ability to apply this knowledge to translational strategy and biomarker design.
• Emerging understanding of the end-to-end clinical development process — from dose escalation through registration — and the strategic role of biomarkers at each stage.
• Ability to work independently and deliver translational programs with regular managerial support; demonstrates sound scientific judgment and prioritization without close oversight.
• Proven ability to operate effectively and demonstrate scientific leadership within cross-functional program teams in a matrixed pharma or biotech environment; understands the roles of Clinical, Ops, Project Management, and HBS Clinical functions in delivering translational work.
• Clearly presents and integrates scientific data across experiments to support a cohesive program narrative; able to articulate the implications of translational findings for Go/No-Go decisions with emerging clarity on risks and caveats.
• Excellent communication and presentation skills for internal stakeholders and emerging external scientific audiences; comfortable representing TM in cross-functional governance settings.

Tech Stack

• Go

Benefits

• qualified retirement programs
• paid time off (i.e., vacation, holiday, and leaves)
• health, dental, and vision coverage in accordance with the terms of the applicable plans