Lead AI Engineer

Reboot Rx is a nonprofit startup focused on advancing affordable cancer treatments by repurposing FDA-approved generic drugs. The Lead AI Engineer will provide strategic technology leadership while hands-on architecting, building, deploying, and operating AI and ML systems, data platforms, full-stack applications, cloud infrastructure, and scientific data solutions. The role also involves collaborating with biomedical scientists, mentoring a technical team, and advancing trustworthy AI for cancer research.

Responsibilities:

• Partner closely with biomedical scientists and other stakeholders to deeply understand their workflows and unmet needs, then design and build innovative solutions that solve their real problems and advance the science
• Help shape and execute the technical strategy and roadmap for our data and AI platform
• Design, build, deploy, and run software end-to-end: full-stack web applications (React front ends, Python API back ends), cloud infrastructure, and data pipelines
• Build agentic AI systems: multi-agent LLM pipelines with tool use, retrieval-augmented generation, and guardrails that make outputs trustworthy (citation verification, hallucination mitigation, human-in-the-loop review)
• Architect and run cloud-native infrastructure on AWS (e.g., Bedrock, Step Functions, ECS/Fargate, Lambda, Aurora/PostgreSQL, S3, OpenSearch) as infrastructure-as-code, with cost-awareness, security, and observability at scale
• Communicate technical work clearly to non-technical audiences, and co-author scientific publications with collaborators where appropriate
• Wear multiple hats and provide light IT general support when needed
• Provide technical leadership and mentorship to a small technical team