Principal Product Manager, Core AI

Twin Health is a digital health company applying AI Digital Twin technology to improve metabolic health and help prevent chronic diseases. The Principal Product Manager will define and build the core intelligence system behind the Digital Twin, including AI agents, human-AI orchestration, conversational interfaces, and platform foundations for personalized health guidance.

Responsibilities:

• Define the Digital Twin intelligence system
• Translate the core loop—Sense → Understand → Decide → Act → Learn—into a scalable agent system
• Define how the Digital Twin reasons, responds, escalates, and coordinates across experiences
• Shape the future of AI-driven health guidance across text, voice, and proactive interactions
• Build specialized agent systems
• Sensor intelligence
• Scheduling and coordination
• Nutrition
• Exercise, sleep, and stress
• Insights
• App help and operational support
• Care-team interaction orchestration
• Build the platform that enables the company
• Create the foundations that allow PMs and teams to build on top of the Digital Twin
• Establish primitives for:
• Agent creation and orchestration
• Memory and personalization
• Evaluation and monitoring
• Define next-generation conversational experiences
• Build deeply personalized experiences across chat, two-way voice, and ambient guidance
• Define conversation patterns and interaction models that feel natural, trusted, and useful
• Operate at frontier speed
• Rapidly move from insight → prototype → experiment → production
• Partner deeply with AI Engineering, Design, Clinical, and Product teams
• Continuously evaluate emerging capabilities across LLMs, speech, memory, and agent systems
• Establish metrics and evaluation systems for:
• Guidance quality
• Conversation effectiveness
• Problem resolution
• Behavior change
• Other duties as assigned

Requirements:

• 8+ years in Product Management (or equivalent impact), including significant experience building AI-native products
• 3+ years building and shipping products powered by:
• LLMs
• Agents
• RAG
• Personalization systems
• Track record of owning complex, system-level products
• Experience shipping conversational or voice experiences with measurable impact
• Strong product judgment and analytical instincts:
• Experimentation
• Evaluation design
• KPI definition
• Builder mindset—you move from concept to shipped system quickly