We are seeking an experienced Portfolio Manager to lead a portfolio of strategic
Manufacturing Execution System (MES) and Digital Manufacturing initiatives within
the Life Sciences industry. This role is responsible for managing multiple programs and
projects across manufacturing sites, ensuring successful delivery of digital
transformation initiatives that improve manufacturing efficiency, product quality,
regulatory compliance, and operational excellence.
The ideal candidate will possess a strong background in pharmaceutical or life sciences
manufacturing, digital manufacturing technologies, MES implementations, and
enterprise program management. This role requires close collaboration with business
stakeholders, manufacturing operations, quality, IT, validation, and external
implementation partners to deliver scalable and compliant manufacturing solutions.
Key Responsibilities
Portfolio Management
Manage and govern a portfolio of MES and Digital Manufacturing programs
across multiple manufacturing sites.
Define portfolio strategy, roadmap, priorities, budgets, and resource allocation.
Monitor portfolio health, delivery milestones, risks, dependencies, and financial
performance.
Establish governance frameworks, executive reporting, and KPI dashboards.
Ensure alignment of manufacturing digital initiatives with organizational business
objectives.
Program & Project Leadership
Lead cross-functional teams responsible for MES implementation, upgrades, and
digital transformation initiatives.
Manage multiple concurrent projects from planning through deployment and
hypercare.
Drive project planning, scheduling, budgeting, vendor management, and
executive communications.
Resolve cross-program risks, issues, and resource conflicts.
Business & Stakeholder Management
Partner with Manufacturing, Quality, Engineering, Supply Chain, Validation, and
IT leadership.
Facilitate executive steering committee meetings and provide regular portfolio
status updates.
Build strong relationships with site leadership and global business stakeholders.
Drive organizational change management and user adoption initiatives.
Digital Manufacturing Leadership
Lead initiatives involving Manufacturing Execution Systems (MES),
Manufacturing Operations Management (MOM), and Smart Manufacturing.
Support manufacturing digitalization initiatives including automation, paperless
manufacturing, electronic batch records, manufacturing analytics, and Industry
4.0 capabilities.
Promote standardization and harmonization of manufacturing processes across
global sites.
Compliance & Quality
Ensure solutions comply with Life Sciences regulatory requirements including:
o GxP
o FDA 21 CFR Part 11
o EU Annex 11
o GAMP 5
o Computer Software Assurance (CSA)
Support validation planning and ensure regulatory readiness for manufacturing
systems.
Financial & Vendor Management
Manage portfolio budgets, forecasts, and financial reporting.
Oversee system integrators, implementation partners, and software vendors.
