Member of the Technical Staff, Generative

Output Biosciences is a company focused on building a biological reasoning model that understands complex biological interactions to generate novel drug treatments. The Member of the Technical Staff will lead the design and development of generative models, working across molecular modalities to create systems that produce biologically grounded molecules.

Responsibilities:

• You will design and build generative architectures for molecular data spanning multiple modalities, including small molecules, peptides, mini proteins and more
• You will develop training approaches that learn from diverse biological signal, ensuring the model composes genuinely novel structures
• You will build methods for controllable, targeted generation, enabling the model to produce molecules with specified biological properties while satisfying real-world chemical constraints
• You will integrate biological reasoning from our foundation model into the generative pipeline, using learned biological representations to guide and condition generation
• You will own training end-to-end: experiment design, distributed training on multi-GPU clusters, hyperparameter optimization, and iteration
• You will design evaluation frameworks that go beyond statistical metrics to measure whether generated molecules are biologically meaningful, structurally valid, and genuinely novel