AI/ML Engineer - Vaccines Modeling and Antigen Discovery

Pfizer is a leading pharmaceutical company seeking an AI/ML Engineer specializing in Vaccines Modeling and Antigen Discovery. The role focuses on leveraging artificial intelligence to enhance vaccine development and translational science, collaborating with various scientific teams to drive innovation in vaccine R&D.

Responsibilities:

• Conduct the development of predictive and multimodal models of vaccine-induced immune responses, including humoral, cellular, systems immunology, and durability readouts
• Advance translational modeling approaches that connect preclinical, clinical, epidemiological, and real-world evidence to support dose selection, patient stratification, correlates of protection, and clinical study design
• Apply foundation models, generative AI, structure-aware learning, protein language models, and sequence-to-function modeling to identify, optimize, and prioritize novel vaccine antigens
• Integrate computational antigen design with experimental feedback loops to improve immunogenicity, breadth, manufacturability, developability, and translational relevance
• Partner across scientific, clinical, data, and technology teams to make vaccine R&D data AI-ready through rigorous data standards, metadata, ontologies, quality control, provenance, governance, and reusable data products
• Design and responsibly deploy agentic AI workflows that support scientific reasoning, literature synthesis, knowledge management, experimental planning, model interpretation, and decision traceability in Vaccine R&D
• Mentor Scientists, Engineers, and cross-functional partners to raise AI fluency, promote responsible adoption, and represent Pfizer’s scientific leadership at the interface of AI, immunology, infectious disease, and vaccine innovation