Design molecular and cellular biology experiments in close collaboration with internal bioinformatics and chemistry teams to support robust in vitro and in vivo screening campaigns.
Manage external CROs, including experimental design, priority setting, technical oversight, data review, timeline management, and proactive troubleshooting to ensure high-quality, timely project execution.
Design and optimize siRNAs, ASOs, PMOs, and other novel nucleotide modalities to enhance therapeutic profiles.
Generate and interpret structure-activity relationships (SAR) to guide lead optimization and candidate selection.
Maintain thorough technical documentation using Electronic Lab Notebooks (ELNs) and effectively communicate experimental strategies, results, and recommendations to multidisciplinary scientific audiences.
Actively evaluate emerging technologies and scientific literature to identify innovative approaches that enhance oligonucleotide potency, extrahepatic delivery, durability, and safety.

Ph.D. in biology, pharmaceutical sciences, or related discipline with 0-6 years of relevant industry experience, OR M.S. with 2-8 years of industry experience in oligonucleotide therapeutic development.
Deep understanding of siRNA and ASO design principles, cellular mechanisms of action, and chemical modification strategies.
Familiarity with state-of-the-art oligonucleotide delivery technologies, including GalNAc conjugates, lipid conjugates, peptide/antibody-oligonucleotide conjugates (AOCs), or other targeted delivery methods.
Hands-on experience with mammalian cell culture, diverse transfection methodologies.

Scientist/Sr. Scientist, Oligo Biology – In Vitro

Key skills