Principal Scientist, Immunology

Role Overview

• Lead immunology-driven research strategy across pipeline programs to support scientific narrative and indication assessment, integrating literature, experimental data, and translational insights
• Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs
• Partner closely with Translational Medicine, Clinical Pharmacology, and Nonclinical teams to ensure alignment of preclinical findings with clinical strategy
• Generate and interpret complex datasets (e.g., cellular immunology, cytokine profiling, pathway analysis), ensuring rigorous and hypothesis-driven conclusions
• Identify and validate new targets and pathways for pipeline expansion, leveraging deep understanding of disease biology, emerging science, and internal platform capabilities
• Evaluate and prioritize new indication opportunities, integrating mechanistic rationale, competitive landscape, and translational feasibility
• Support external collaborations and CRO activities, providing scientific direction and technical oversight to ensure high-quality data generation
• Author and contribute to scientific documents, including study reports, regulatory sections (e.g., IND-enabling rationale), presentations, and publications
• Present findings to internal governance teams and external scientific forums
• Stay current with advances in immunology, inflammation, and translational science, applying new insights to strengthen program and pipeline strategy

Requirements

• PhD in Immunology or related field with 8–12+ years of relevant industry experience is required
• Deep expertise in immunology and disease biology, particularly in autoimmune and inflammatory disease mechanisms
• Strong understanding of drug development, including how preclinical and translational data inform clinical strategy
• Experience with immunological assays and platforms (e.g., flow cytometry, ELISA/MSD, cytokine panels, cellular assays); familiarity with advanced platforms (e.g., single-cell, proteomics) is a plus
• Experience working in cross-functional teams (e.g., Translational Medicine, Clinical, Nonclinical)
• Strong written and verbal communication skills, with a track record of scientific publications and presentations
• Ability to operate independently while contributing to a collaborative, fast-paced biotech environment.