Senior Director, Clinical Scientist

Role Overview

• Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company developing cell therapies for patients suffering from autoimmune diseases.
• Lead the scientific and operational execution of clinical programs focused on Multiple Sclerosis.
• Develop, lead, and maintain study protocols, informed consent forms, clinical study reports, and other key study documents.
• Mentor and potentially manage Clinical Research Scientists.
• Partner with Clinical Operations, Biometrics, Regulatory, Medical Affairs, and Commercial teams to ensure alignment on clinical strategy and execution.
• Write and review scientific content of key clinical and regulatory documents.
• Review and interpret safety, efficacy, MRI/imaging, biomarker, laboratory, relapse, and disability progression data throughout study conduct.
• Collaborate with CROs and vendors to ensure high-quality study execution, enrollment performance, operational excellence, and inspection readiness.
• Support the monitoring of patient safety during study conduct and appropriate tracking, escalation, and follow-up of adverse events and protocol deviations.
• Represent Clinical Development in high-impact external settings including advisory boards, regulatory meetings, investigator meetings, and scientific congresses.

Requirements

• Advanced scientific or clinical degree required (PhD, PharmD, MD or equivalent).
• 10+ years of progressive experience in clinical research, clinical development, and global late-stage clinical trial management within biotechnology or pharmaceutical industries.
• Significant experience supporting or leading Multiple Sclerosis clinical development programs required.
• Experience in cell therapy, gene therapy, immunology, autoimmune disease, or related therapeutic areas strongly preferred.
• Deep understanding of neuroimmunology, autoimmune disease biology, MS clinical endpoints, biomarkers, imaging, and treatment landscape.
• Demonstrated success developing and executing clinical strategies across multiple programs, including late-stage global clinical trials.
• Strong knowledge of GCP, ICH guidelines, global regulatory frameworks, regulatory requirements, and clinical trial methodology.
• Strong operational acumen with the ability to independently lead complex projects in fast-paced, highly matrixed organizations.
• Experience interpreting complex clinical datasets, including safety, efficacy, biomarker, laboratory, and imaging data.
• Experience with investigator-initiated and/or collaborative research trials preferred.
• Prior management experience strongly preferred.
• Excellent verbal, written, presentation, and interpersonal communication skills.
• Proven ability to support strong relationships with internal stakeholders, external investigators, KOLs, regulators, and scientific collaborators.
• Experience working in fast-paced and evolving biotech environments preferred.
• Willingness and flexibility to travel up to 15% for congresses, investigator meetings, advisory boards, and clinical site visits as needed.

Tech Stack

• Google Cloud Platform

Benefits

• annual bonus
• equity
• benefits
• participation in the Company’s stock plan